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Found 6 with your filter

AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)

Kd: 4.40E+3nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM17055((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)

Kd: 960nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 1.30nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

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AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM50024294(SP-600125)

Kd: 35nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Kd: 130nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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AP2-associated protein kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)

Kd: 2.30E+3nMAssay Description:Average Binding Constant for AAK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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MCE
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Filter my 653 hits

Targets 111▿
- Tyrosine-protein kinase ABL1 66
- Ephrin type-A receptor 6 15
- STE20-like serine/threonine-protein kinase 14
- Cyclin-G-associated kinase 13
- Tyrosine-protein kinase Lck 12
- Serine/threonine-protein kinase 10 11
- Ephrin type-B receptor 1 10
- Platelet-derived growth factor receptor beta 10
- Mitogen-activated protein kinase 9 10
- Tyrosine-protein kinase FRK 10
- TRAF2 and NCK-interacting protein kinase 9
- Ephrin type-A receptor 5 9
- Tyrosine-protein kinase ABL2 9
- MAP kinase-interacting serine/threonine-protein kinase 2 9
- Epidermal growth factor receptor 9
- Cyclin-dependent kinase 16 8
- Mast/stem cell growth factor receptor Kit 8
- Serine/threonine-protein kinase PLK4 8
- Mitogen-activated protein kinase kinase kinase kinase 5 8
- Mitogen-activated protein kinase 10 8
- Ephrin type-A receptor 8 8
- Proto-oncogene tyrosine-protein kinase Src 8
- Casein kinase I isoform epsilon 8
- Receptor-interacting serine/threonine-protein kinase 2 8
- Receptor-type tyrosine-protein kinase FLT3 7
- Serine/threonine-protein kinase 17A 7
- Ribosomal protein S6 kinase alpha-2 7
- Ephrin type-A receptor 3 7
- Dual specificity protein kinase CLK1 7
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 7
- Dual specificity protein kinase CLK4 7
- Dual specificity protein kinase CLK2 7
- BMP-2-inducible protein kinase 7
- Tyrosine-protein kinase HCK 7
- AP2-associated protein kinase 1 6
- Ephrin type-B receptor 4 6
- Ephrin type-A receptor 4 6
- Mitogen-activated protein kinase 12 6
- Tyrosine-protein kinase Yes 6
- Vascular endothelial growth factor receptor 2 6
- Vascular endothelial growth factor receptor 3 6
- Calcium/calmodulin-dependent protein kinase kinase 2 6
- Serine/threonine-protein kinase 36 6
- Serine/threonine-protein kinase ULK3 6
- Serine/threonine-protein kinase 3 5
- Dual specificity protein kinase TTK 5
- Ephrin type-A receptor 2 5
- Serine/threonine-protein kinase 4 5
- Serine/threonine-protein kinase 17B 5
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 5
- Mitogen-activated protein kinase 11 5
- Death-associated protein kinase 3 5
- Mitogen-activated protein kinase kinase kinase 4 5
- Tyrosine-protein kinase Fyn 5
- High affinity nerve growth factor receptor 5
- Tyrosine-protein kinase Lyn 5
- Cyclin-dependent kinase 5 5
- Serine/threonine-protein kinase pim-2 5
- Receptor tyrosine-protein kinase erbB-2 5
- Mitogen-activated protein kinase 8 5
- Ribosomal protein S6 kinase alpha-5 5
- Angiopoietin-1 receptor 5
- Calcium/calmodulin-dependent protein kinase type 1D 5
- Protein-tyrosine kinase 6 5
- Mitogen-activated protein kinase 14 5
- Tyrosine-protein kinase Fgr 5
- Fibroblast growth factor receptor 1 5
- Aurora kinase C 5
- Cyclin-dependent kinase 2 4
- Death-associated protein kinase 2 4
- Serine/threonine-protein kinase 38-like 4
- Myosin light chain kinase 2, skeletal/cardiac muscle 4
- Serine/threonine-protein kinase MARK2 4
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 4
- Dual specificity protein kinase CLK3 4
- Tyrosine-protein kinase CSK 4
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 4
- Calcium/calmodulin-dependent protein kinase kinase 1 4
- Aurora kinase A 4
- Fibroblast growth factor receptor 2 4
- Calcium/calmodulin-dependent protein kinase type II subunit beta 3
- Tyrosine-protein kinase Fer 3
- Serine/threonine-protein kinase Nek2 3
- Tyrosine-protein kinase BTK 3
- Serine/threonine-protein kinase pim-1 3
- Serine/threonine-protein kinase 16 3
- Focal adhesion kinase 1 3
- Ribosomal protein S6 kinase alpha-3 3
- Tyrosine-protein kinase JAK2 3
- Activated CDC42 kinase 1 3
- Calcium/calmodulin-dependent protein kinase type 1G 3
- Calcium/calmodulin-dependent protein kinase type 1 3
- Fibroblast growth factor receptor 3 3
- Tyrosine-protein kinase SYK 2
- Cytoplasmic tyrosine-protein kinase BMX 2
- LIM domain kinase 1 2
- Calcium/calmodulin-dependent protein kinase type II subunit delta 2
- Casein kinase I isoform gamma-2 2
- Casein kinase I isoform gamma-1 2
- Insulin receptor 2
- Protein kinase C alpha type 2
- Serine/threonine-protein kinase PAK 1 2
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 2
- Serine/threonine-protein kinase PAK 4 1
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Tyrosine-protein kinase JAK1 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase PAK 3 1
- ...
Publications 1▿
- Nat Biotechnol 23: 329-36 (2005) 653
Institutions 1▿
- Ambit Biosciences 653
Affinity: 0.020 to 1.0E+4 nM▿
- Kd 653
- Affinity ≤ nM
Xtal structures: 12
Docked structures: 8
Catalog Cmpds: 19